Welcome to Experimental Immunology Lab
About us
Our lab focuses on the understanding of fine-tune regulation of homeostatic interaction between microbiota and host immune system. Specifically, how changes in microbiota composition and function are changing immune responses. Special attention is paid to the early postnatal period when both microbiota and immune system are developing, and mutual homoeostatic interactions are being set. Caesarean section delivery and early postnatal antibiotics administration impact microbiota development, thus delaying neonatal immune system maturation. Probiotic administration seems to be a rational way for promoting immune system maturation and/or a correction for dysbiosis.
Recent Publications
Probiotics
Effect of early postnatal supplementation of newborns with probiotic strain E. coli O83:K24:H31 on allergy incidence, dendritic cells, and microbiota
Súkeníková L, Černý V, Thon T, Roubalová R, Jirásková Zákostelecká Z, Novotná O, Petrásková P, Boráková K, Kocourková I, Lodinová-Žádníková R, Musil Z, Kolářová L, Prokešová L, Valenta Z, Hrdý J.
Frontiers in Immunology (2023)
doi: 10.3389/fimmu.2022.1038328
Parasitology
Toxocara canis infection worsens the course of experimental autoimmune encephalomyelitis in mice
Novák J, Macháček T, Majer M, Kostelanská M, Skulinová K, Černý V, Kolářová L, Hrdý J, Horák P
Parasitology (2022)
Probiotics
The impact of Escherichia coli probiotic strain O83:K24:H31 on the maturation of dendritic cells and immunoregulatory functions in vitro and in vivo
Súkeníková L, Černý V, Věcek J, Petrásková P, Novotná O, Vobruba Š, Procházka J, Michalčíková T, Kolářová L, Prokešová L, Hrdý J.
Cells (2022)
doi: 10.3390/cells11101624
Available Positions
Master student
Master students are welcome to apply to perform a diploma thesis in our laboratory.
Master students can choose from multiple themes carried out in the laboratory to work on.
Postgraduate students
Postgraduate students can choose from multiple themes based on the grants available and their research interests.
Current open project for Ph.D. students
The role of dysbiosis on proportional and functional characteristics of particular neutrophil subsets
Role of neutrophils in health and disease
Effect of early postnatal probiotic supplementation on maturation of neonatal immune system